Knowing the costs– Applied Common Sense

Interesting article in the NY Times about costs of the criminal justice system. Missouri has taken the radical step of informing judges the cost of various sentence options:

For someone convicted of endangering the welfare of a child, for instance, a judge might now learn that a three-year prison sentence would run more than $37,000 while probation would cost $6,770. A second-degree robber, a judge could be told, would carry a price tag of less than $9,000 for five years of intensive probation, but more than $50,000 for a comparable prison sentence and parole afterward. The bill for a murderer’s 30-year prison term: $504,690.

One presumes somewhere in the system is a mechanism to look at value and efficacy!?

“One of the flaws in the operation of our criminal justice system is not only the failure to be attentive to cost but an arrogance that somehow you can never put a price on justice. Long missing has been a sober realization that even if we get significant benefits from incarceration, that comes at a significant cost.”

Where have I heard something like this before?

“No one can put a price tag on being a victim,” said Scott Burns, executive director of the National District Attorneys Association.

What’s fascinating is the parallel issue of cost in medicine. In medicine, prices are rarely revealed and considered in the treatment decision. As a matter of fact, we (patients, providers, and payers) are price insensitive when treating serious medical problems and will readily accept very costly approaches that have little efficacy.

Medicynical Note: Patients aren’t informed, have infinite expectations of treatment and cure, and insurers pay whatever is demanded. As a result we are going bankrupt, individually and as a nation.


Glucosamine, Chonroitin = Placebo

Back from vacation.

Alternative medicine in most instances is an expensive placebo. There are benefits to alternative providers and the drug does provides something to do for patients who must do something–even if it’s no better than doing nothing.

The British Medical Journal this week published a meta-analysis of several trials of the use of glucosamine and chondroitin–alternative treatments for arthritis. Even my vet recommends these drugs.

Unfortunately these agents don’t work! The study concluded:

Compared with placebo, glucosamine, chondroitin, and their combination do not reduce joint pain or have an impact on narrowing of joint space. Health authorities and health insurers should not cover the costs of these preparations, and new prescriptions to patients who have not received treatment should be discouraged.

Medicynical Note: The broader issue “efficacy” should be considered in both the marketing of medications and payment by insurance. In this case the “drug” is inexpensive (though there are 2 billion dollars in sales annually around the world) and it’s not a huge issue except as a matter of honesty in marketing.

But there are a number of expensive drugs that offer results little or no better result than placebo but at prohibitive cost. Should insurers pay? Medicare has no authority to deny payment for drugs that are FDA approved even those with little benefit. It’s a reason why our system is bankrupting us.


Palliative Care: Improved Outcomes in Metatstatic lung cancer

An article and editorial in this week’s NEJM on the beneficial effect of early use of palliative supportive care on survival in metastatic lung cancer.

The editorial notes;

The specific components of the study’s palliative care intervention remain unspecified and hence may not be easily reproducible in other practice settings. For example, the salutary effect of additional time with and attention from health care providers and physicians, as opposed to a specific benefit derived from palliative care itself, was not assessed and is a limitation of the study. The reasons for the 2.7-month survival benefit in the palliative care group — a benefit that is equivalent to that achieved with a response to standard chemotherapy regimens — are unknown but may result from effective treatment of depression, improved management of symptoms, or a reduction in the need for hospitalization.

Medicynical note: A 2.7 month survival benefit is, as noted, equal or better to that achieved not only with standard chemotherapy but also to that (if any) attained with the newer super expensive targeted agents. For example with Avastin at nearly $100,000/year –“The median survival was 12.3 months in the group assigned to chemotherapy plus bevacizumab, as compared with 10.3 months in the chemotherapy-alone group (hazard ratio for death, 0.79; P=0.003).” –an improvement of just 2 months. (NEJM 2006;355:2542-2550)

This is however a small study and the results need confirmation, perhaps with more detail on the palliative interventions used. Cost would be of interest as well.


Avastin — If it doesn’t work (in breast cancer), why use it? A triumph of marketing over reasoning!

The FDA will decide shortly whether to continue Avastin’s metastatic breast cancer indication. The article in the Post puts it in terms of “freedom” to choose any treatment regardless of cost or efficacy. However when a drug doesn’t work for the indication, what’s the rationale for it’s use?

An FDA advisory committee voted 12 to 1 on July 20 to withdraw Avastin’s authorization for advanced breast cancer based on two new studies that the advisers concluded had not shown that the drug extends life. Not only that, the committee concluded that the studies indicated the drug slowed tumor growth for even less time — perhaps as little as about a month. “The vast majority opinion of the committee was that the drug was not doing very much, and what it was doing was more than offset by the negative,” said Wyndham Wilson of the National Cancer Institute, who chaired the committee. Avastin can cause a variety of potentially serious side effects, including blood clots, bleeding and heart failure. “In our best judgment, we did not feel this drug was safe to give relative to its benefits,”

And of course the republican response:

I fear this is beginning of a slippery slope leading to more and more rationing under the government takeover of health care that is being forced on the American people,” said Sen. David Vitter (R-La.).

Medicynical Note: There may be some utility for Avastin in breast cancer but the studies show no survival benefit. Desperate cancer patients will try virtually any therapy that may offer a benefit, this is particularly the case where there is no or little financial participation in covering the costs. The irony in Senator Vitter’s “concern” is that his party’s solution to health care, the so called free market, formalizes economic rationing of care (if you don’t have the money you don’t get the care). Our non-system is bankrupting patients, insurers, and the country. We need some rationale, like efficacy, to decide which treatments to use and pay for. Of course individuals should be free to buy whatever therapy they wish whether it works or not–and considering the boon in the Mexican cancer hospitals along the border, they do.


More on Free Markets — Not good for your health

Economix continues the discussion of the inappropriateness of free market health care. Reinhardt’s discussion includes references to Kenneth Arrow’s 1960’s work on the characteristics of a perfectly competitive market.

Arrow explored in the early 1960s what the characteristics would be of a perfectly competitive market for an ordinary commodity, how the medical care industry deviated from those characteristics and what aspects of health care might explain these deviations.

And:

On the other hand, as medical science and practice advance rapidly, the information gap between physicians and their patients increases. Many transactions in the market for health care therefore still proceed on the basis of trust in the expertise and integrity of physicians and other health workers, rather than on the countervailing power of equally well-informed buyers and sellers, each looking out only for their own self-interest.

And Arrow in a recent interview:

I think the basic analysis hasn’t changed. There are wars over the details, but the basic analysis is accepted. Some specifics have changed. If you look closely at my argument there is a sociological structure. There is a kind of sociological thesis. The market won’t work –it doesn’t work well in the health context. But something else supplements the market, and the thing I put stress on in the paper are the elements that put a non-economic influence on the market: professional commitments to provide a service, to engage in services that aren’t self-serving. Standards of caring decided by non-economic actors. And one problem we have now is an erosion of professional standards. In a way there is more emphasis on markets and self-aggrandizement in the context of health care, and that has led to some of the problems we have today. (medicynical emphasis)

Medicynical note: So as the blind faith movement pushes for “free” i.e. less regulated markets in health care we should be painfully aware of the failures of this movement in the financial area (both in the 80’s and more recently), the deregulation of electric power (Enron, in case you forgot) etc. We shouldn’t forget that money makes people do funny things.

Health care is different than other commodities, it’s not optional; often there are no alternatives; shopping for care is difficult because of the urgency of needed care and the information gap — both the diagnosis of and the likely consequences of treatment are asymmetrically allocated between the sell-side (providers) and the buy-side (patients) of the health care market.”

In the free market of ideas it’s buyer beware of those selling a free market idea for health care.


Representative Ryan’s Plan for Medicare–Explicit Economic Rationing of Care

In and op-ed Representative Ryan of Wisconsin outlines his play for taking Medicare apart.

Given that we spend one and a half to two times as much on health care than other industrialized nations it’s clear we have to change. Indeed as Ryan notes there is predicted “38 trillion shortfall” over the next 75 years.

So there is a problem and Ryan seems to object to the savings outlined in the recent health care reform bill even if it’s savings attained through smarter spending and choosing the best most efficient treatments.

Instead his radical solution is to gut Medicare and replace it with “vouchers” to be used to “apply” to a list of medicare certified coverage options. No discussion of the amount of money the voucher will provide; the coverage it will buy; whether it will cover the premium; whether it will suffice if the premium is raised because of illness; whether the “certified coverage option” can turn the beneficiary down for coverage; and so on.

There is no discussion of what he means by “additional support” for those who have low incomes and higher health costs, and what he means by high-income beneficiaries–what is high income in the context of retirement? He is therefore proposing a replacing a simple system of insurance which has very low administrative costs with one that will have to evaluate and adjudicate the level of government support for, I would predict, the great majority of beneficiaries.

Left unclear is how this will cut costs in our very inefficient health care system other than create a system where economic rationing of care is the rule.

Medicynical note: There must be a better way. This may be a way to start a discussion but is a totally inadequate solution to the problem. The U.S. is the only country in the world without a national health care system. Ryan’s solution won’t change that.


Free Market Health Care = Economic Rationing of care

This is not rocket science but simply how markets work.


What they didn’t tell you about Provenge (sipuleucel-T)

In the past year there have been several notable, and expensive, reconsiderations of drugs. Erythropoietin after years of use and billions spent was shown to worsen outcomes and Avastin in breast cancer, again after billions spent, was shown to do nothing to improve outcome.

It’s therefore a medicynical imperative to look at new drugs and their reported efficacy and cost.

Provenge (sipuleucel-T) has been greeted with great enthusiasm. It  does offer “hope” for certain prostate cancer victims.

When one reads the small print of the studies that resulted in FDA approval (July 29, 2010 NEJM), it turns out that the drug has very limited benefit especially considering the cost ($93,000) for one month’s treatment.

The Kaplan-Meier survival curves tells the tale. (see the article for the shape of the curve) The following summarizes that data:

No. Patients at         0            12        24          36         48         60
Risk in months

Sipuleucel-T           341          274    129          49           14          1
Placebo                    171           123      55          19            4           1

When comparing the surviving cohorts note that there was a 2:1 randomization.

From the small numbers in the study it’s apparent that a very small difference in the selection or disease biology in just a few patients  could account for the survival “differences.”  Consider at 1 year the difference taking into account the 2:1 randomization is just 28 patients, at two years 19 patients and at 36 months just 10.  At 60 months one patient survived in each group.  Another way of putting it is that for the $93,000/patient cost or 33 million dollars for the entire group treated,   at one year there was a mere 28 patient differential in survival between the treated and placeobo.  That’s a cost of over a million dollars a patient for the benefit at one year.

There are other problems with the study as noted in the accompanying editorial:

The median survival was 25.8 months in the sipuleucel-T group, as compared with 21.7 months in the placebo group (unadjusted hazard ratio for death in the sipuleucel-T group, 0.77; P=0.02). Study-group assignment had no significant effect on the time to tumor progression; 1 of 341 patients in the sipuleucel-T group had a partial tumor response, and 3% had a reduction of at least 50% in PSA level on two visits at least 4 weeks apart. Thus, the improvement in survival came without evidence of a measurable anti-tumor effect.

And:

First, a better control group would have included patients receiving PBMCs incubated with GM-CSF alone so that the main variable between the two study groups would be the tumor antigen.

And:

Second, the prolongation of survival without a measurable anti-tumor effect is surprising. It is hard to understand how the natural history of a cancer can be affected without some apparent measurable change in the tumor, either evidence of tumor shrinkage or at least disease stabilization reflected in a delay in tumor progression. This lack of tumor effect raises concern that the results could have been influenced by an unmeasured prognostic variable that was accidentally imbalanced in study-group assignments.

And:

Another concern with sipuleucel-T treatment is the cost. The current cost of care for men with prostate cancer has been estimated to be about $1,800 per month.10 The manufacturer has set the cost of a 1-month course of sipuleucel-T at $93,000, or $23,000 per month of survival advantage. The high cost may affect use. It is also uncertain what role sipuleucel-T will ultimately play in the treatment of prostate cancer, given the other promising treatments in development.

Medicynical note: This is an exceptionally expensive drug with an exceptionally limited benefit. No evidence of tumor regression save a transient decrease in PSA in 3% of patients and just a 4 month median survival benefit. Worth the money?  Thinks the results will be confirmed?

Carpe Diem would appear this drug company’s watchword.


Market Based Health Care Patent Reform

This is from an earlier Medicynic (Jan 4, 2009). It’s here because of Reinhardt’s continuing discussion in economix of market based health care.

George Will and Mike Leavitt think buying health care should be like buying a car:

“Leavitt says that until health care recipients of common procedures can get, up front, prices they can understand and compare, there will be little accountability or discipline in the system: “In the auto industry, if the steering-wheel maker charges an exorbitant price, the car company finds a more competitive supplier. In health care, if the medical equipment supplier charges an exorbitant price, none of the other medical participants care.””

Price should be part of the health care equation. The cost of everything should be up front and open to scrutiny. Insurers should bargain for the best deal for their customers. These negotiated prices should be common knowledge so that all needing health care can benefit.

What’s missing from Mr. Will’s analysis is an understanding that patients are not in a position to shop health care. Finding the “best price” for emergency care and most other health care needs is simply not possible and the patient has to take whatever is available from the local supplier at the demanded price. Furthermore, health care is not like other commodities that people can take or leave as they wish. Buying a car or even a new home is an optional expenditure, health care is not. Yet health care costs/year for an individual can now approach and exceed these large expenditures.

Patient’s health care decisions reflect their anxiety, personal bias, financial status and understanding of the situation. This last factor should not be underestimated. Patients in the majority of instances cannot fully understand the risks and/or benefits of treatments and the alternatives, much less concern themselves with cost efficiency data. He/she is thus greatly influenced by physicians, manufacturers, insurers, etc. all with superior knowledge of the situation. All these advisors have extreme conflicts of interest that interfere with unbiased advice and undermine the notion of a “free health care market”–it doesn’t exist.

Our health care market doesn’t encourage efficiency, but rather it promotes over utilization. Providers and suppliers make more when there is consumption of health care services and products. One only has to experience inaccurate and highly deceptive TV ads for pharmaceuticals and procedures to understand that consumption is the name of the game, not cost efficiency.The failure of free market forces in health care is graphically demonstrated in the insurance market. Insurers, in the U.S., spend an estimated 30% of revenue on administrative costs while other industrialized countries manage with between 7 and 15% for administrative costs–that’s over 100 billion dollars wasted. Our expenditures/capita are similarly elevated. Even with these excess expenditures, 50 million of our citizens are uninsured. CEO’s of insurance companies understand they are in business to make money and not deliver and/or pay for quality economical care. Much less provide health care for all.

There is even worse inefficiency in the pharmaceutical industry where products are given generation long monopolies (patents) that eliminate price competition. Companies price drugs based on the severity of the condition rather than their costs of development. They figure more seriously ill people can be coerced into paying more. They have been correct thus far. In the U.S. free markets are interpreted to mean free to make maximum profit.


Health Care IS Different

Nice discussion in Economix by Ewe Reinhardt:

The crucial characteristics of a perfectly competitive market are (1) that all of the quality dimensions of the good or service traded in that market are accurately understood by buyer and seller; (2) that potential buyers have full transparency on the price they will have to pay per unit of that good or service; (3) that it is easy and relatively costless for potential sellers to enter and exit this market; (4) and that there are so many potential buyers and sellers that none individually can affect the market price of the thing being traded.

Read the full article but also look here and then here and here for a medicynical view.