Category Archives: Health Economics

Market Manipulation (Compath)

Campath, a drug used for chronic lymphatic leukemia, has been found to have some activity in multiple sclerosis. The manufacturer, Genzyme Corp., is under pressure of a hostile buyout and is in discussions with Sanofi regarding the liklihood of future profits for this drug, as noted here. In the article the difference in pricing for Campath as a leukemia drug and as a potential MS treatment was noted:

Most MS drugs, such as Biogen Idec Inc’s (BIIB.O) Tysabri, cost more than $40,000 a year. A new oral drug made by Novartis AG (NOVN.VX) called Gilenya costs roughly $50,000 a year.

Campath sells for a fraction of that. As a result, Genzyme has to persuade governments and insurance companies to pay a higher price for the drug as a treatment for multiple sclerosis than it does as a treatment for cancer.

Genzyme says it is confident it can find a way to do it — possibly by withdrawing the drug from the market as a cancer treatment and providing it for nothing.*

Medicynical Note: Drugs costing tens of thousands of dollars per year trade on the desperation of patients with serious illness and are part of reason our health care expenses are soaring. (17% of GDP) From the above it’s clear that Compath was profitable at the lower price charged chronic leukemia patients. Seeing an opportunity to charge more for a larger patient population the company of course does what any for for profit enterprise would do, gouge their customers.

Shouldn’t health care be different? Can such market manipulation be legal, after all these drugs are protected by a government provided monopoly (patents)? Or perhaps should this type government intervention in “free” markets (patent protection) be done away with?

*Addendum: I note on December 22 that the above discussion of pricing has been removed from the Reuters article. Why? Too embarrassing?

However, the quote can be found on the CNBC site here. (and also on other sites by googling the text)


Herceptin, Tykurb in Breast Cancer : What wasn’t reported

Tis the season of the San Antonio Breast Conference and the season of overstatements–most often by people with drug company ties.

There was an interesting report on combining Herceptin (trastuzumab) and Tykurb (lapatinib) in Her2neu positive breast cancers.

The report studies neoadjuvant use of targeted treatment in breast cancer. That is, treatment prior to surgery with the goal of shrink tumors, making breast conservation more possible and hopefully improving patient survival.

What wasn’t noted in the report:

1. Neoadjuvant therapy with conventional drugs alone results in drug shrinkage and complete response in about 25% of patients,and improves breast conservation rates, but shows no survival advantage after several years study.
2. Neo adjuvant treatment including Tykurb and Herceptin (the current study) shows shrinkage of tumors and improved ability to do breast conservation surgery. BUT, despite the hooplah, no survival studies have been completed. It is not known whether the drugs actually improve survival.
3. The drugs are only effective when used on the small group, 15-20% of breast cancer patients, who have overexpression of Her 2 neu.
4. The cost of the two drugs in combination is at least $10,000/month, probably more. Added to the other drugs used, doctors fees the cost for this treatment is probably around $20,000/month.

Medicynical Note: I recall a patient of mine who informed me, when told he would have to pay $38/pill for a new anti-nausea drug, that he’d rather throw up than pay that. He seems somewhat prosaic given the current inflation of cancer drug costs.

You better believe that cost is a major issue, particularly in a non-system that is bankrupting us. In what other area of consumer commerce would $20,000/month be spent?

In this study half the patients apparently have little or no response. So let me rephrase the question. In what other area of consumer commerce would $20,000/month be spent on a product which only works half the time (if every one of the responding patients lived longer, which is extremely doubtful). Consider also the impact of 13 months treatment at $20,000/month (4 months pre-surgery and 9 months post), that is $260,000 for drugs alone–not counting the costs for the 50% of patients that don’t respond, a minimum it seems of 4 months of treatment, $80,000.

The issue now and in the future is likely cost. Who will pay? How? A further issue is how can an industry produce and market drugs so inefficiently that costs are so high?

Economic Rationing of Health care is Here in Arizona– and elsewhere too!

Opponents of health reform tell us our non-system provides the best health care in the world and that we don’t “ration” health care.

In fact we have had economic rationing of health care for years. Arizona’s repulican governor Brewer’s denying transplants for medicaid patients is just the latest example. The Times looks at this policy of “death by budget cut.”

Effective at the beginning of October, Arizona stopped financing certain transplant operations under the state’s version of Medicaid. Many doctors say the decision amounts to a death sentence for some low-income patients, who have little chance of survival without transplants and lack the hundreds of thousands of dollars needed to pay for them.

Francisco Felix, 32, a father of four who has hepatitis C and is in need of a liver, received news a few weeks ago that a family friend was dying and wanted to donate her liver to him. But the budget cuts meant he no longer qualified for a state-financed transplant.

Such high drama is unfolding regularly here as more and more of the roughly 100 people affected by the cuts are becoming known: the father of six who died before receiving a bone marrow transplant, the plumber in need of a new heart and the high school basketball coach who struggles to breathe during games at high altitudes as she awaits a lung transplant.

Medicynical Note: This is the future of the U.S. non-system of health care without reform. The facts are that we need to find ways to be more efficient, provide value in care and assure that those who can be successfully treated receive that treatment.

At present our non-system is inefficient, provides poor value (we’re #1 in the world in percapita costs by 50% or more) and have numerous people who are being denied care on economic grounds. This in what was once the most successful economy in the world.

Why our non-system is soooo inefficient and costly

Article at the National Bureau of Economic Research by David Cutler notes: (Body of article is behind pay wall)

Cutler begins by noting that productivity growth has been much slower in health care than in most other sectors of the economy. In other industries, productivity growth has been driven primarily not by the development of new goods but by new ways of organizing production, distribution, and sales, changes that jointly have resulted in more output per dollar of inputs. In health care, by contrast, there has been very little organizational innovation.

His analysis of the process of medicine identifies three issues resulting in high cost and inefficiency. First, in many instances such as prostate cancer and coronary artery disease and cancer of the elderly we provide expensive aggressive interventions that yield little survival benefit. Second he notes the poor coordination of our system so that for example diabetics often do not get optimal care–in the summary he does not discuss the influence of cost on this lack of care. Third he comments on the high cost of providing care and suggests greater use of technology and such interventions as checklists to improve the outcomes. I’m unconvinced by this part of the analysis

Medicynical Note:  Participants in our non-system  game it to increase revenue and profits  for providers–procedures over other care– suppliers, and insurers.

Quality, efficiency and value are not part of the equation.

Our Health Care System: Inefficiency, is that a problem?

The Washington Times presents a tortured argument against promoting more efficient care in the most expensive health care non-system in the world.

Think of it, a centralized, federal database tracking your every visit to a health care provider – where you went, who you saw, what was diagnosed and what care was provided. Chilling.  Medicynical note: as if private insurers oversight that  controls and limits treatment given is less intrusive, or as if the data will have patient identifiers.

The Times takes issue with the notion of efficiency in health care.  To them, apparently,   spending 50% more per capita on health care than any other nation in the world and 17% of GDP, and increasing yearly, is acceptable:

There is no telling what metrics will be used to define the efficiencies, but it is clear who will bear the brunt of these decisions. Those suffering the infirmities of age, surely, and also the physically and mentally disabled, whose health costs are great and whose ability to work productively in the future are low. And how will premature babies fare under the utilitarian gaze of Washington’s health efficiency experts? Will our severely wounded warriors be forced to forgo treatments and therapies based on their inability to be as productive as they once might have been? And will the love between a parent and child have a column on the health bureaucrats’ spreadsheets?

The Times then goes on to compare cost efficacy measures with the nazis.

Medicynical note: Nothing surprising here. Until we show some will to control  costs our non-system caring for an aging increasingly health care needy population will continue to spend our nation’s wealth.

Our republican friends have been amazingly quiet about their solutions. Their “free market” rhetoric leads one to assume they would put an increasingly large burden of expense on individuals–their form of individual mandate. They would then let the costs of health care assure economic rationing. For those who can’t afford care, I suppose their solution for patients is that of 18th century France and will let them eat cake.

Medicare Hospital Pricing — Cost plus

Our health care non-system is remarkable for it’s high cost and the resultant inability of individuals to afford insurance and care (50,000,000 uninsured).  Ewe Reinhardt’s discussion on hospital pricing helps understand the exceptional costs we pay for hospitalization and the inefficiency of the system.

He notes the origin of the Medicare hospital reimbursement mechanism:

this was a home-grown American idea that Presidents Ronald Reagan and George H.W. Bush embraced and introduced to Medicare.

He explains the differences between the amount paid by private insurers and Medicare:

Private insurers pay hospitals mainly on the basis of negotiated per-diem rates,

A natural byproduct of one-on-one negotiations is price discrimination, which means that a hospital charges different insurers different prices for the same service, and that a given health insurer pays different hospitals substantially different prices for the same service Medicynical Note:  Some remarkable price differences   without evidence of difference in outcomes.

Medicare pays on a different basis:

Medicare uses what is known as the “case base” system for paying hospitals for inpatient care, which means that hospitals receive one single payment for an entire inpatient episode of a given type.

The medicare payment is corrected for a number of factors including case severity, type of hospital, the amount of non-reimbursed care offered by the hospital and so on –read the article for more.

Medicynical Note:  Medicare’s system seems reasonable, though there have been noted to be wide geographical variations in payments reflecting differences in local economies, local inefficiencies and gaming of the system.

As we work to make Medicare more efficient and economical perhaps with a budget based system, reimbursements  will need to be rebalanced with fewer rewards for procedures and high tech interventions and more for those involved in face to face care.

Campath for Multiple Sclerosis — A Primer on Drug Marketing

This from Bnet is enough to make a Medicynic’s day:

If Campath is approved for MS, Genzyme would face several choices, both moral and economic:

It could rebrand Campath as an MS drug and sell it in MS-dose-sized ampules for thousands of dollars more. But that would lead to an uproar from MS sufferers who would know they’re being exploited. And it might lead to doctors splitting up 30mg ampules intended for CLL patients and diverting the supply to MS patients.

It could leave Campath at the same price for CLL — but that would destroy the existing MS drug market and drug companies are generally loathe to implode lucrative disease categories when they present themselves.

It could withdraw the drug completely for CLL but promise to continue supplying those patients free of charge, and then relaunch Campath as an expensive MS-only product. That might prevent MS patients migrating to diverted CLL doses, but it would also be controversial.

Medicynic: How about providing an effective drug at minimal cost

Health Care — Why it’s Bankrupting us

Interesting comparison in costs of health care here.

Medicynical Note: Argument in favor of these costs is that we, an altruistic nation, pay more to encourage innovation.

Argument against is that we are suckers, padding the profits of international and domestic corporations who don’t give a damn about health care. Our non-system is simply the least efficient and most costly in the world.

Take your pick.

Health Care is about the money, Care? Not our department

This from Health Care For America.

The six largest investor owned health insurance companies recorded huge profit gains in the third quarter of 2010 by spending a smaller share of premiums on medical care, purging unprofitable members and burdening consumers with higher cost-sharing limits.

The companies, Wellpoint Inc., United Health Group Inc., Aetna inc., Humana inc., Cigna Corp and Coventry Health Care

made combined profits of $3.4 billion in the three months ending Sept. 30.

Medicynical Note: The money came, in part, from reducing the proportion of premiums spent on health care–Coventry is down to 76.8%, Aetna at 80.5%.

In 1993 95% of premium dollars went for health care. By 2007 the average amount spent on care was down to about 80%,

In comparison with other industrialized nations:

Performance on measures of health system efficiency remains especially low, with the U.S. scoring 53 out of 100 on measures gauging inappropriate, wasteful, or fragmented care; avoidable hospitalizations; variation in quality and costs; administrative costs; and use of information technology. Lowering insurance administrative costs alone could save up to $100 billion a year at the lowest country rates.

Only in America would such inefficiency tolerated. Amazing.


Efficacy testing of drugs OK in U.K. –Financial Times

The issue of testing advances for efficacy and value in health care is one of the sticking points for our conservative friends. They oppose such testing and feel that everyone should have infinite choices, no matter the cost or limited efficacy. And Medicare and many other insurers should simply pay and pass through the additional costs. How else to interpret their criticism of comparison testing and evaluation of efficacy in the health reform bill–and the cost savings built into it.

There is however a voice of reason somewhere. (Financial Times November 7, 2010)

But the principle is justified: a centralised body is needed systematically to assess whether a drug offers therapeutic advantages and is cost-effective. Otherwise, in a health system with finite funding, such treatments will squeeze out others offering better outcomes.

In practice, Nice should be involved in establishing value too. Its role could be extended to rule on what constitutes a fair price at the time of launch with periodic amendments as greater clinical use better demonstrates value.

Medicynical note: Of course in the U.S. we don’t have finite funding. We think it’s perfectly all right to spend twice as much as other industrialized countries per capita on health care and eat up almost 20% of GDP. Value in medicine? An archaic concept when the profits of the medical industrial complex are involved.