Category Archives: General Cynicism

Sending the Wrong Signal to Big Pharma–Drug reform and generics

It’s too bad that health care reform has been gutted by special interests. In addition to the Nelson and Landrieu obscenities drug companies have taken advantage.

This is not new behavior for these guys. The patented drug pharmaceutical industry has always been in the forefront of dubious practices aimed at making money, not improving care.

I can recall as a senior medical student being taking for a weekend to New York, all paid for by a drug company. On graduation these so called “ethical” pharmaceutical companies gifted students with doctor bags, books, and instruments all for the purpose of maintaining brand consciousness.

It’s therefore a little disconcerting to watch these same interests work to undermine parts of health “reform” to maintain their grip on products and pricing. Included in the bill are:

extensive protections against generic versions of pricey biotech medicines, an incentive for Medicare recipients to use more brand-name drugs,

more, not less, patent protection for drugs costing more than most U.S. citizens make in a year.

Like the House bill, the Senate bill gives the Food and Drug Administration power to allow biogenerics onto the U.S. market. Such protein-based medicines treat cancer and other conditions but can cost tens of thousands of dollars a year per patient.
Generic makers welcomed the pathway to approval, but the bills provide for a 12-year period of exclusivity for brand-name drugs before a biogeneric can be approved. The Obama administration had sought just five to seven years of protection. (Medicynical emphasis)

Drug companies claim they need the protection to recoup research costs. But if they have to charge $10,000/month and more for new biotech drugs then they are either exceptionally inefficient (FYI they spend tens of billions on marketing which they have to also recoup), or the drug is simply too expensive for our system to afford. Sadly to this point most of these new agents offer only slight, if any (that is no proven survival benefit) over other therapies. Paying a premium for such agents is a little nuts.

The Senate seems to have outdone itself in protecting drug companies, how about something for U.S. taxpayers who will be paying the bills for these new but, so far, marginally effective drugs.


Cost Containment in Health Reform–Not this reform

Alain Enthoven has a review of the problems of cost containment.

Ultimately the reason we need health reform is because our costs exceed our ability to pay. The current bill doesn’t approach this issue. It is more a bill designed to protect the income and profits of the current players than to reform it.

Enthoven’s solution:

What should be done? I explained it in my “Consumer Choice Health Plan” articles in the 1978New England Journal of Medicine. The idea is also in a recent report by the Committee for Economic Development (CED). The general idea is for government to pay everyone’s way into the purchase of an efficient or low-cost health plan, meeting standards in their state or region but no more; if people want something that costs more, they must pay the difference with their own net after-tax dollars. Additionally, the creation of exchanges that broker multiple choices of health plans would drive the delivery system to produce better value through consumer choice and competition.


Advertising and Health Care–What’s a lay person to think?

Our opposition party health care plan, if you can find it, seems to favor free market approaches and free emergency room access.

Such a vague “plan” leaves moot the issue of the influence of Madison Avenue on patient decisions. Drug companies, for example, spend tens of billions of dollars on advertisements to influence patients. They must have a significant effect, how else to explain their continuing and increasing prevalence.

It’s therefore concerning, particularly if you think markets are the answer, that physicians and institutions use ads to overstate their capabilities and results.

Medicynical Note: We live in a manipulated world. There is really no free and open market. In health care. Most people cannot hope to be fully informed and understand their medical problems, treatments and options. The internet has sources of widely varying quality. To understand this, simply Google (or Bing) a diagnosis, and try to sort through and find the evidence based information.

Ineffective and modestly effective approaches are being actively marketed for use at horrific cost to the individual and the system. Hopefully this will be reformed.


B12 and Folic Acid May increase the risk of Cancer and Death

The alternative medicine community operates in a cloud (claims without hard evidence) based in part on the notion that whatever they do has to “improve the immune system.” There is little basis for this claim in improved outcomes, other than placebo effect.

A recent study in the Journal of AMA (JAMA. 2009;302:2119-2126) reports on a two placebo controlled studies from Norway in which patients received folic acid and vitamin B12.

The results indicate an excess of 3.5 new cases/1000/year and one excess case of lung cancer per 1,000 per year

Patients were followed for over three years. More patients receiving the vitamins were diagnosed with cancer (10% vs 8.4% P=.02) and more receiving the vitamins died (4% vs 2.9% P=.01). Another way of stating this, if we wanted to maximize the claim, would be that there was an almost 16% increase in cancer diagnoses and a 28% increase in death. Medicynical note: whenever you hear a percentage increase or decrease in something you can assume it overemphasizes the result.

About all that one can say about this study is that, regarding cancer prevention, B12 and folate offer no benefit and may even increase the risk.

Medicynical Note: One explanation of the finding is that in addition to whatever “positive” effects there are, B12 and folate also enhance the growth of cancer cells in some patients. One needs to be careful about therapeutic weapons that “enhance” something because they have double edges and enhance the wrong thing.


Health Care Reform–Not nearly perfect, it may not even be good…..

It’s fascinating to watch our flawed legislative system “work.” Buy offs, illegitimate martinets demanding their 15 minutes, deals with money hungry corporate entities, bribery at every level, compromises until it’s hard to recognize what’s really been accomplished and complexity that violates the KISS principle. It’s certainly not pretty, efficient or effective.

Despite all that the resulting bill improves the current dysfunctional non-system and should be passed. This conclusion is more a comment on the current pathetic state of health care in America than an unqualified endorsement.

In a “two party” democracy one would have thought the opposition would have something to offer. But in this case the best they could do was maintain that free emergency room care was the answer to our health care problems. Incredible.

The bill allows insurers to rate on age but appears to stop the practice of varying rates according to illness.

‘‘(a) IN GENERAL.—With respect to the premium rate charged by a health insurance issuer for health insurance coverage offered in the individual or group market—
‘‘(1) such rate shall vary only by— ‘‘(A) family structure; ‘‘(B) community rating area; ‘‘(C) the actuarial value of the benefit; ‘‘(D) age, except that such rate shall not
vary by more than 2 to 1; and
‘‘(2) such rate shall not vary by health status- related factors, gender, class of business, claims ex- perience, or any other factor not described in paragraph (1).

The publicity on the bill claims no one can be denied coverage and that rates will not be increased (presumably after issuance) for a pre existing illness. It does sanction a 3:1 increase based on increasing age, hardly a people friendly policy. Considering that the average cost of insurance for a family is in the range of $10,000, such variation in charges are prohibitive. If this is so it’s hardly a benevolent system or one in which the health and well-being of those covered is the primary objective.

See this in LA Times

Companies in the exchanges would have to offer policies to all customers, regardless of their health status. Insurers could not charge older people more than three times what they charge their youngest customers, an unprecedented national restriction on what is known as age-rating.

It’s also unclear what the bill will do to decrease costs to a more reasonable level; to rein in corporate profits; or whether it will provide objective evaluations of the effectiveness of outrageously expensive therapies and improve efficiency.

Until we are more concerned with patients than corporate profits our health care will be costly and, for the amount spent, mediocre.

Medicynical Note: I’m in awe of a health care system that can charge $20 for a flu vaccine and then add $38 to the bill as a fee for the injection–as I was recently billed. We need to put the health care reform ball in play and make changes in its trajectory as we go.


Doctor Ratings on the Web: Meaningless, inaccurate and dangerous

I’m in favor of unbiased ratings of physicians on the web but am unimpressed by the quality and accuracy of the information currently available. (The following information was found Dec 18, 2009)

Mark Weinberger M.D. from the RateMD’s website.

Dr. Mark Weinberger
Merrillville, IN
Gender: M
Specialty: Ear, Nose and Throat
Webpage:

This is taken from the free section of the rating on healthgrades.com. It also showed a 4 star out of 5 star rating of quality of care.

Dr. Mark Weinberber practices
Otolaryngology in Merrillville, Indiana
Address and Contact Information
255 East 90th Drive Suite 1
Merrillville, In, 46410
Specialties:
Otolaryngology.

Medicynical notes: These sites are ludicrous. This guy has been a fugitive from malpractice litigation since 2004. He was arrested yesterday in Italy where he has been hiding.

Other inaccuracies in doctor ratings may not be so obvious. A patient’s best source of information is likely a combination of recommendations from doctors the patient knows and trusts and other patient’s experiences.

In a similar vein, information about illness and approaches to treatment on the web are of widely variable quality. The alternative medical sites (“naturopathic” and “homeopathic”) often misrepresent themselves and their capabilities and provide misleading and sometimes tragically bad information.

As in everything in our society it’s buyer beware.


The Dark Side of Health Care Reform–Funding unproven quackery

Quite amazingly health reform, which has as one of it’s bases the use of evidence based therapies, will fund alternative remedies that can be, at best, explained as placebo medicine.

Acupuncturists, dietary-supplement makers and other alternative health practitioners, some of whose treatments are considered unproven by the medical establishment, would be brought more squarely into the mainstream of American medicine under the health legislation now before the Senate.

The legislation would allow doctors to incorporate alternative health providers in some treatment plans. It also includes language that some believe could require insurance companies to expand their coverage for alternative therapies, on which Americans now spend $34 billion a year.

This is of course what the “life extension” crew has been waiting for. There appears no proven basis for these remedies or their unsubstantiated wild claims of extending life. This is pure fantasy, not science.

These remedies cost money. They make people feel good that they are doing “something” but the benefit, if any, appears limited to that of a placebo. The question is how much should a health care system spend on placebos?

Medicynical note: The main concern here is the unproven supplements on which we spend billions. This would be added to our current expenditures and undermine any cost savings of health reform. Additionally, such remedies will on occasion delay truly effect therapy being employed.


A new low (i.e. high price) $30,000/month (Folotyn)–Your money or your life, maybe

The maybe in the title is because no one knows whether this new $30,000/month drug (Folotyn) works to prolong life.

And Folotyn has not even been shown to prolong lives — only to shrink tumors. The drug was approved by the Food and Drug Administration in late September as a treatment for peripheral T-cell lymphoma, a rare and usually aggressive blood cancer that strikes an estimated 5,600 Americans each year.

and later in the article:

But Dr. Newcomer said insurers would be obligated to pay for Folotyn because there were no alternatives.

Medicynical note: Even if this new drug worked perfectly in 100% of cases can any health care system afford such pricing? Think of it as sophisticated blackmail rather than health care and you get the idea.

Of course this is simply the most egregious example of drug company gouging. Pricing drugs proportional not to costs or benefit but on how desperate the patient is. A more cynical approach is hard to imagine.

This drug is a poster child for patent reform. We’ve argued that patent length (government sanctioned monopolies) should be dependent to some extent on responsible pricing. If a drug is priced ridiculously the patent should be of shorter duration. The more reasonably priced the advance, the longer the patent–a market solution to price gouging.


Consistancy is not one of their strong points

Those forthright opposers of “socialized” medicine the republican party:

Ronald Reagan: “[I]f you don’t [stop Medicare] and I don’t do it, one of these days you and I are going to spend our sunset years telling our children and our children’s children what it once was like in America when men were free.” [1961]

George H.W. Bush: Described Medicare in 1964 as “socialized medicine.” [1964]

Barry Goldwater: “Having given our pensioners their medical care in kind, why not food baskets, why not public housing accommodations, why not vacation resorts, why not a ration of cigarettes for those who smoke and of beer for those who drink.” [1964]

Bob Dole: In 1996, while running for the Presidency, Dole openly bragged that he was one of 12 House members who voted against creating Medicare in 1965. “
I was there, fighting the fight, voting against Medicare . . . because we knew it wouldn’t work in 1965.” [1965]

McCain October 17, 2008:

The Wall Street Journal reported earlier this month that McCain would cut Medicare and Medicaid funding by $1.3 trillion dollars over the next decade to keep his plan budget-neutral — based on estimates by independent analysts — and that McCain’s campaign had acknowledged his plan would pay for his health care tax credits in part with savings from the two programs. The paper said the campaign had not given a specific figure for the cuts, but did not dispute the analysts’ estimate.

Now the great defender of Medicare and in favor of maintaining excessive Medicare spending. McCain December 3, 2009:

Sen. John McCain of Arizona, Obama’s Republican opponent in last year’s presidential race, laid bare the political nature of the debate by making a recording to be telephoned automatically to thousands of voters in states represented by Democrats, urging the deletion of the Medicare cuts.

Medicynical note: Consistently inconsistent. The heck with values, judgement, the greater good or for that matter health care. That appears to be the republican way.


Baffle em with your BS–PhARMA

Nice article at TPM on pharmaceutical manufacturers manipulating the market. After all money is what it’s all about. Health care, pshaw!

Congress is thinking of doing something about it. PhARMA’s memorable response:.

  • “Patent settlements between brand-name and generics companies can resolve expensive patent disputes to help foster innovation and improve access to medicines so that patients can live healthier, more productive lives.” Medicynic: Huh? Improve access by charging more?
  • “Law and public policy have always favored settlements, including patent settlements. PhRMA continues to believe that legislation that would impose a blanket ban on certain types of patent settlements or otherwise prevent them could decrease the value of patents and reduce incentives for future innovation of new medicines. This is also unnecessary because the Federal Trade Commission (FTC) and others already have the authority to review and evaluate any patent settlement agreement between a brand name company and a generic company. The courts and enforcement agencies like the FTC are in the best position to review these settlements on a case-by-case basis to ensure that they are not harmful to competition. By imposing a general ban or imposing harsh disincentives, pending legislation would effectively remove the decision-making process from this appropriate venue.”

Medicynical note: So call “ethical” (they used to call themselves this) pharmaceutical manufacturers pay off generic companies, some would say bribe, to not market generics that compete with their branded drug. It’s apparently legal but highly disadvantageous to consumers. A free market, no! Guess who pays?